மருந்து மற்றும் மருந்து விநியோக ஆராய்ச்சி இதழ்

Formulation and Characterization of Paracetamol Co-crystals for Enhanced Bioavailability

Das S, Das S, Pattanayak D, Hossain CM and Jithan AV

Bioavailability is an important factor in effective therapeutic activity. A drug with low bioavailability can have the problem with solubility or permeability. Paracetamol, also known as acetaminophen is a medication used to treat pain and fever. Paracetamol is generally safe at recommended doses. Paracetamol is classified as a mild analgesic. It belongs to BCS class III. A pharmaceutical co-crystal is a single crystalline solid that incorporates two neutral molecules, one being an active pharmaceutical ingredient (API) and the other a cocrystal former. In the present study co-crystals of paracetamol were prepared using different co-former. Different ratio of urea, succinic acid and tartaric acid were used to design the cocrystals. They were formulated by two different methodscooling crystallization and solvent evaporation. The prepared cocrystals were evaluated for Product yield, Surface morphology. (SEM), Fourier Transform Infrared Spectroscopy, Micromeretic properties, drug content, Dissolution study of cocrystals, stability studies. The results indicated that cocrystals prepared by using a suitable co-former can definitely enhance the dissolution rate ultimately leading to enhanced bioavailability