ஜர்னல் ஆஃப் லிவர்: நோய் மற்றும் மாற்று அறுவை சிகிச்சை

The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients

Zuhal Mert Altintas, Engin Altintas, Orhan Sezgin, Tuba Gokdogan Edgunlu, Enver Ucbilek, Erdinc Nayir, Ibrahim Omer Barlas and Mehmet Emin Erdal

The Effect of Genetic Variations of Methylene Tetrahydropholate Reductase Gene Polymorphisms on Ribavirin-Induced Anemia in Hepatitis C Patients

Ribavirin is a purine nucleoside analogue. Even though its mechanism of action is still controversial, it widely prevents the replication of DNA and RNA viruses through the inhibition of inosine monophosphate dehydrogenase, an essential enzyme in the synthesis of guanosine triphosphate. Currently, the treatment of patents with hepatitis C consists of interferon-α and ribavirin combination therapy.