William J. Rowe
About us:
“5th International Conference on Genome Editing and Gene Therapy” will be held in Osaka, Japan during August 19-20, 2020. Major attractions of this event would revolve around keynote presentations, oral presentations and poster presentations. This year we are focusing on the theme “Innovation Techniques Involved in Genetics and Genome Summaries". Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserts genetic material into a host genome, genome editing targets the insertions to site specific locations. In 2018, the common methods for such editing used engineered nucleases, or "molecular scissors". These nucleases create site-specific double-strand breaks (DSBs) at desired locations in the genome. The induced double-strand breaks are repaired through no homologous end-joining (NHEJ) or homologous recombination (HR), resulting in targeted mutations ('edits').
Genome editing with engineered nucleases, i.e. all three major classes of these enzymes—zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and engineered meganucleases—were selected by Nature Methods as the 2011 Method of the Year. The CRISPR-Cas system was selected by Science as 2015 Breakthrough of the Year.
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