Kathrin Becker, Sebastian Schroecksnadel, Simon Geisler, Marie Carriere, Johanna M. Gostner, Florian ?berall, Nathalie Herlin and Dietmar Fuchs
Effects of TiO2 Nanoparticles on Human Myelomonocytic Cell Line THP-1
The frequency of exposure to nanoparticles has remarkably increased throughout recent years. Titanium dioxide (TiO2) materials are commonly used for consumer and health care products as well as for technical and medicinal applications. Recently, both suppressive and stimulatory effects of TiO2 nanoparticles on human peripheral blood mononuclear cells have been shown, indicating T-cell - macrophage interactions to be an important target for nanoparticle action.
To address the impact of nanoparticles on isolated monocytes, we investigated effects of TiO2 nanoparticles on the human myelomonocytic cell line THP-1 in vitro and monitored the influence
of particle treatment on tryptophan breakdown in unstimulated and lipopolysaccharide (LPS)-stimulated cells in this study.
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