லா ப்ரென்சா மெடிகா

Prophylactic Effect of a Low Dose of Tranexamic Acid on Reducing Bleeding in Septorhinoplasty

Jahangir Ghorbani, Shideh Dabir, Sara Roudgari and Nasim Raad

Background: Intraoperative bleeding and postoperative periorbital edema and ecchymosis are the main concerns in septorhinoplasty surgery. Tranexamic acid, an antifibrinolytic agent, is used to reduce bleeding in nasal surgeries. The aim of this prospective double blind, randomized, controlled study was to assess the efficacy of a prophylactic low dose of tranexamic acid on bleeding and periorbital edema and ecchymosis in open septorhinoplasty. Methods: 52 American Society of Anesthesiologists class I adult patients scheduled for open septorhinoplasty under total intravenous anesthesia were randomized into 3 groups to receive either a bolus dose of 500 mg oral or intravenous tranexamic acid or placebo prior to the surgery. Results: There were no significant differences in the intraoperative bleeding between the groups. The grade of periorbital edema and ecchymosis on the first, third, and seventh days after surgery were similar in the three groups. Conclusions: The efficacy of a prophylactic single dose of 500 mg tranexamic acid on the intraoperative bleeding and postoperative edema and ecchymosis was similar to that of placebo in open septorhinoplasty.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை